Once an mRNA has been produced, by transcription and processing the information present in its nucleotide sequence is used to synthesize a protein.
SEQUENCE OF MRNA CRACKED
And indeed, not only has the code been cracked step by step, but in the year 2000 the elaborate machinery by which cells read this code-the ribosome-was finally revealed in atomic detail.Īn mRNA Sequence Is Decoded in Sets of Three Nucleotides Here was a cryptogram set up by nature that, after more than 3 billion years of evolution, could finally be solved by one of the products of evolution-human beings. This feat of translation first attracted the attention of biologists in the late 1950s, when it was posed as the “coding problem”: how is the information in a linear sequence of nucleotides in RNA translated into the linear sequence of a chemically quite different set of subunits-the amino acids in proteins? This fascinating question stimulated great excitement among scientists at the time. In this section we examine how the cell converts the information carried in an mRNA molecule into a protein molecule.
However, most genes in a cell produce mRNA molecules that serve as intermediaries on the pathway to proteins. In the preceding section we have seen that the final product of some genes is an RNA molecule itself, such as those present in the snRNPs and in ribosomes.
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